藥物警訊

Docetaxel: Drug Safety Communication - May Cause Symptoms of Alcohol Intoxication

AUDIENCE: Oncology

ISSUE: FDA is warning that the intravenous chemotherapy drug docetaxel contains ethanol, also known as alcohol, which may cause patients to experience intoxication or feel drunk during and after treatment. FDA is revising the labels of all docetaxel drug products to warn about this risk.

BACKGROUND: Docetaxel is a prescription chemotherapy drug used to treat different kinds of cancer, including cancers of the breast, prostate, stomach, head and neck cancers, and non-small-cell lung cancer.

RECOMMENDATION: Health care professionals should consider the alcohol content of docetaxel when prescribing or administering the drug to patients, particularly in those whom alcohol intake should be avoided or minimized and when using it in conjunction with other medications.

Read the MedWatch safety alert, including a link to the FDA Drug Safety Communication. at:http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm402106.htm

FDA發布安全警訊，化療藥品docetaxel，因藥品內含有酒精，可能會使病人在治療過程中或治療後出現酒精中毒或感到酒醉之症狀。FDA擬修改所有docetaxel藥品仿單以加註此風險。

背景：化療處方藥品docetaxel適用於治療多種癌症，如乳癌、前列腺癌、胃癌、頭頸癌和非小細胞肺癌等。

建議：醫療人員開方或給藥時，應將docetaxel之酒精成分以及其併用的其他藥物一同納入考量，尤其某些應避免或減少服用酒精之病人更應留意。

相關訊息與連結請參考FDA網址：http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm402106.htm

資料來源：美國FDA之藥物安全警訊
資料提供：台大醫院藥劑部